Analgesics and nonsteroidal anti-inflammatory drugs are used to reduce pain and eliminate inflammation. The path to the discovery of anesthetics was difficult and long. In the past, only folk remedies had been used for these purposes, and during the surgery the role of anesthetics was played by alcohol, opium, scopolamine, Indian hemp, and even such inhumane methods as stunning blow to the head or partial asphyxiation. In folk medicine to relieve pain and fever willow bark had long been used. Later it had been discovered that the active ingredient in willow bark was salicin, which is converted by hydrolysis into salicylic acid. Acetylsalicylic acid was synthesized as early as 1853, but it had not been used in medicine until 1899, until people found out about its effectiveness for arthritis and good endurance. Only after that the first drug of acetylsalicylic acid was introduced, which is now known worldwide as Aspirin. Since then, the number of synthesized compounds of different chemical nature, which suppress pain not causing the loss of consciousness, were discovered. These means are called analgesics (from the Greek algos - pain). Those that do not cause addiction, and in therapeutic doses do not inhibit the activity of the brain, are called non-narcotic analgesics. Since most of them additionaly have anti-inflammatory properties, they are called "Non-narcotic analgesics and nonsteroidal anti-inflammatory drugs."
These substances are able to suppress the symptoms and signs of inflammation, including pain, because the reduction of the intensity of the inflammatory process leads to a decrease of pain. Furthermore, they reduce high body temperature, which means they have antipyretic effect, which is being exerted due to the thickening of skin vessels’ surface and strengthening of the heat emission.
The group of non-narcotic analgesics and nonsteroidal anti-inflammatory drugs are the drugs with different chemical structures and with different ratios of analgesic and anti-inflammatory effect. The mechanism of anti-inflammatory and analgesic action of NSAIDs is associated with inhibition of the enzyme specific - COX, contributing to the synthesis of prostaglandins - the major mediators of inflammation and pain. At the same time, they affect the synthesis and the transformation of other substances within the body (e.g. bradykinin) involved in the occurrence and distribution of inflammation and pain.
Generic Accupril is used to treat high blood pressure and heart failure and for preventing kidney failure due to hypertension and diabetes.
Generic Arcoxia is selective COX-2 inhibitor, in therapeutic concentrations blocks the formation of prostaglandins and anti-inflammatory, analgesic and antipyretic effect.
Generic Cymbalta is a popular medicine that has been labeled as serotonin and noradrenaline reuptake inhibitor (SNRI) antidepressant. It diminishes symptoms of fibromyalgia, depression, generalised anxiety disorder (GAD) and nerve pain (peripheral neuropathy) in diabetics.
Generic Feldene is used to treat articular syndrome (rheumatoid arthritis, infectious-allergic disease of the connective tissue group, characterized by chronic progressive inflammation of the joints, osteoarthritis, inflammation of the joints and adjacent bone, ankiloziruyushy spondylitis, vertebral disease, gout), back pain, neuralgia, myalgia (muscle pain), traumatic inflammation of soft tissues and opornodvigatelnogo apparatus, primary dysmenorrhea in patients older than 12 years, acute infectious-inflammatory diseases of the upper respiratory tract.
Generic Indocin is a nonsteroidal anti-inflammatory drug (NSAID) that reduces fever, pain and inflammation.
Generic Motrin can be used in adults for relief of the symptoms of rheumatoid arthritis and osteoarthritis, treatment of menstrual pain, and relief of mild to moderate pain.
Generic Naprosyn is nonsteroidal anti-inflammatory drug, is used to relieve the stiffness, inflammation, swelling, and joint pain associated with juvenile arthritis, ankylosing spondylitis (spinal arthritis), bursitis, acute gout, tendinitis, rheumatoid arthritis and osteoarthritis (the most common form of arthritis); it is also used to relieve menstrual cramps and other types of mild to moderate pain.
Generic Nimotop is used to decrease problems due to a certain type of bleeding in the brain (subarachnoid hemorrhage-SAH).
Generic Ponstel is a nonsteroidal anti-inflammatory medication, is used for the relief of moderate pain and for the treatment of menstrual pain.
Generic Pyridium is analgesic, used for pain relief for inflammatory diseases of the bladder and urinary tract infections (such as cystitis and urethritis).
Generic Relafen is used in treatment of inflammatory and degenerative diseases of the musculoskeletal system: rheumatoid arthritis, osteoarthritis.
Generic Tegretol reduces seizures and nerve pain such as diabetic neuropathy, "restless legs", migraine headache, trigeminal neuralgia (severe pain in the lips, eye, chin, cheek, gums, alcohol withdrawal, emotional disorders (depression and abnormally aggressive behavior), cocaine addiction, bipolar disorder and epilepsy.