NSAIDs are very widely used in almost all the departments of medicine. By some estimates, each year in the world more than 60 million prescriptions of non-aspirin NSAIDs are being produced. However, the actual number of patients taking NSAIDs is much more, since this medication is approved for use as a non-prescription medicines.
The action of NSAIDs at the cellular level is associated with the inhibition of the enzyme cyclooxygenase-2 (COX-2), which leads to disruption of the synthesis of prostaglandins (PG) - proinflammatory cytokines.
Anti-inflammatory effect is manifested at weakening stage of exudation (edema) and proliferation (proliferation of connective tissue). Violation of PG synthesis leads to a decrease of the selection of biologically active substances that activate inflammation (histamine, serotonin), increase membrane permeability and increase swelling. Reduction of edema happens due to the normalization of the vascular permeability of membranes during inflammation. Important role in the anti-inflammatory effect of NSAIDs is played by their antioxidants whose main property is to inhibit lipid peroxidation (LPO), the products of which are the free radicals that damage biological membranestion, therefore contributing to the progression of inflammation.
NSAIDs have a broad spectrum of side effects, including the three major groups: NSAID-induced gastropathy, drug damaged articular cartilage, and cardiovascular complications. The greatest number of side effects is associated with disorders of the gastrointestinal tract. Minimal (but not eliminated) risk of side effects on the gastrointestinal tract is caused by preferential and selective COX-2 blockers, which requires a combination of them with a proton pump blockers (omeprazole and others).
Generic Arcoxia is selective COX-2 inhibitor, in therapeutic concentrations blocks the formation of prostaglandins and anti-inflammatory, analgesic and antipyretic effect.
Generic Aristocort is used for treatment a variety of medical conditions, including but not limited to, insufficiency of the adrenal cortex, inflammatory disorders, allergic disorders, and connective tissue disorders.
Generic Asacol (mesalamine) is known as a popular delayed-release medicine. It curtails diarrhea, ulcerative colitis, proctosigmoiditis, signs of ulcerative colitis from recurring.
Generic Azulfidine is a drug with anti-microbial and anti-inflammatory properties. Azulfidine has mainly a general anti-inflammatory effect due to better absorption (up to 30% of applied dose).
Generic Dexone is used for short-term treatment of steroid-sensitive treatment of infectious and inflammatory eye diseases and external ear after exclusion of fungal and / or viral etiology and, if necessary, local antibiotic therapy.
Generic Estrace is used in prophylaxis postmenopausal osteoporosis in women who have passed at least five years after menopause.
Generic Feldene is used to treat articular syndrome (rheumatoid arthritis, infectious-allergic disease of the connective tissue group, characterized by chronic progressive inflammation of the joints, osteoarthritis, inflammation of the joints and adjacent bone, ankiloziruyushy spondylitis, vertebral disease, gout), back pain, neuralgia, myalgia (muscle pain), traumatic inflammation of soft tissues and opornodvigatelnogo apparatus, primary dysmenorrhea in patients older than 12 years, acute infectious-inflammatory diseases of the upper respiratory tract.
Generic Ilosone is used to treat infections of the upper and lower respiratory tract, atypical pneumonia, purulent-inflammatory diseases of the skin and its appendages, diphtheria, erythrasma, gonorrhea, syphilis, listeriosis, Legionnaires' disease, prevention and treatment of rheumatism in case of intolerance of beta-lactam antibiotics.
Generic Indocin is a nonsteroidal anti-inflammatory drug (NSAID) that reduces fever, pain and inflammation.
Generic Mobic is used to treat fever, arthritis, osteoarthritis and primary dysmenorrhea. Mobic reduces hormones that cause swelling, stiffness, pain, tenderness and inflammation in the organism.
Generic Motrin can be used in adults for relief of the symptoms of rheumatoid arthritis and osteoarthritis, treatment of menstrual pain, and relief of mild to moderate pain.
Generic Naprosyn is nonsteroidal anti-inflammatory drug, is used to relieve the stiffness, inflammation, swelling, and joint pain associated with juvenile arthritis, ankylosing spondylitis (spinal arthritis), bursitis, acute gout, tendinitis, rheumatoid arthritis and osteoarthritis (the most common form of arthritis); it is also used to relieve menstrual cramps and other types of mild to moderate pain.
Generic Ponstel is a nonsteroidal anti-inflammatory medication, is used for the relief of moderate pain and for the treatment of menstrual pain.
Generic Relafen is used in treatment of inflammatory and degenerative diseases of the musculoskeletal system: rheumatoid arthritis, osteoarthritis.