Generic Diuretics medications
Diuretics (diuretics) are the substances that stimulate the kidneys to increase urine formation and thus helping to remove liquids and minerals from the body (increase urine output).
Diuretics are divided into three groups depending on application of their action, which depends on the severity of the natriuretic effect, expressed as a percentage of sodium excreted from the total amount of sodium filtered in the glomerulus.
Potent diuretics (causing more than 15-20% excretion of filtered sodium):
- Organic mercury compounds (Mersalil, is currently used in clinical practice);
- acid derivatives sulfamonlantranilovoy (Furosemide, bumetanide, piretanid, torasemide);
- phenoxyacetic acid derivatives (Ethacrynic acid, indakrinon).
Diuretics with moderate natriuretic effect (causing excretion of 5-10% of filtered sodium):
- benzotiadiazin derivatives (thiazides and gidrotiazidy) (Hlortiazid, hydrochlorothiazide, bendroflumethiazide, politiazid, cyclothiazide);
- heterocyclic compounds similar to the mechanism of tubular action of thiazide diuretics (Chlorthalidone, metolazone, klopamid, indapamide, ksipamid).
Light diuretics (causing excretion of less than 5% of filtered sodium):
- Potassium-sparing diuretics (Amiloride, triamterene, spironolactone);
- carbonic anhydrase inhibitors (Acetazolamide);
- osmotic diuretics (Mannitol, urea, glycerol).